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Oxaliplatin: Detection and Management of Hypersensitivity Reactions
Barbara B Rogers1, Terri Cuddahy1, Caralyn Briscella1
1Fox Chase Cancer Center.
Clinical Journal of Oncology Nursing
|January 26, 2019
Summary
Oxaliplatin hypersensitivity reactions (HSRs) are a significant clinical challenge. Nurses require education on preventing, detecting, and managing these reactions, especially after six infusions.
Area of Science:
- Oncology
- Clinical Pharmacy
- Nursing Practice
Background:
- Oxaliplatin is a vital chemotherapy agent for gastrointestinal cancers and other malignancies.
- Hypersensitivity reactions (HSRs) to oxaliplatin can impede treatment efficacy.
- Nurses are central to oxaliplatin administration and HSR management.
Purpose of the Study:
- To review oxaliplatin-associated HSRs, including symptoms, management, and prevention.
- To discuss the role of desensitization and skin testing in managing HSRs.
- To outline the essential role of nurses in HSR care.
Main Methods:
- Literature review on oxaliplatin HSRs.
- Focus on diagnosis, prevention, and management strategies.
- Emphasis on the nursing role in patient care.
Main Results:
- Oxaliplatin HSRs can manifest at any treatment cycle.
- Patients face the highest risk of HSRs after six oxaliplatin infusions.
- Early identification and management are crucial.
Conclusions:
- Effective management of oxaliplatin HSRs is critical for patient outcomes.
- Nurses are key in preventing, detecting, and managing HSRs.
- Further research into risk identification, like skin testing, is warranted.
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