Related Experiment Video
Updated: Jan 30, 2026
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Oxaliplatin: Detection and Management of Hypersensitivity Reactions
Barbara B Rogers1, Terri Cuddahy1, Caralyn Briscella1
1Fox Chase Cancer Center.
Background:
Oxaliplatin is used extensively for the treatment of gastrointestinal cancer and other malignancies, with increased frequency of use in recent years. Hypersensitivity reactions (HSRs) can pose a major problem in clinical practice because they can limit the use of oxaliplatin in the care of malignancies in which it has proven efficacy. Nurses play an integral role in the administration of oxaliplatin; therefore, they need to be well educated in the prevention, detection, and management of HSRs.
Objectives:
This article reviews the symptoms of HSRs associated with oxaliplatin, the specific management of HSRs associated with oxaliplatin, the role of desensitization, and the potential use of skin testing to better identify patients at risk for HSR.
Methods:
This article reviews the literature related to the diagnosis, prevention, and management of HSRs associated with oxaliplatin and outlines nurses' role.
Findings:
Oxaliplatin HSRs can occur at any cycle, but patients are at highest risk after they have received six prior infusions of oxaliplatin.
Related Concept Videos
01:30Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
02:06Allergic Reactions
03:06Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
02:53Determining Order of Reaction
02:22Reaction Yield
02:53Reaction Rate
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...