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Intriguing relationship between antihypertensive therapy and cancer
Marijana Tadic1, Cesare Cuspidi2, Evgeny Belyavskiy1
1Charité - Universitätsmedizin Berlin, Department of Internal Medicine and Cardiology, Augustenburgerplatz 1, 13353 Berlin, Germany.
Pharmacological Research
|January 26, 2019
Summary
Arterial hypertension is common in cancer patients, often induced by anti-cancer therapies. This review examines the complex, debated relationship between antihypertensive drugs and cancer outcomes, noting conflicting research findings.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Arterial hypertension is a frequent cardiovascular risk factor in cancer patients.
- Anti-cancer therapies often induce hypertension and cardiotoxicity, necessitating antihypertensive medication.
- The interplay between antihypertensive drugs and cancer outcomes is a subject of ongoing debate with conflicting evidence.
Purpose of the Study:
- To comprehensively review and summarize current knowledge on the relationship between antihypertensive medications and cancer.
- To highlight the conflicting findings and potential mechanisms linking antihypertensives and cancer.
- To address the heterogeneity in studies investigating this association.
Main Methods:
- Literature review of existing studies on antihypertensive medications and cancer.
- Analysis of research investigating the effects of various antihypertensive classes on cancer occurrence, recurrence, complications, and mortality.
- Synthesis of data considering patient heterogeneity (age, cancer type, comorbidities) and anti-cancer therapy.
Main Results:
- Conflicting results exist regarding the effect of antihypertensive drugs on cancer, ranging from adverse to beneficial.
- Some studies deny negative impacts on cancer, while others report decreased mortality in cancer patients using antihypertensives.
- Mechanisms underlying the antihypertensive-cancer relationship remain largely hypothetical.
Conclusions:
- The relationship between antihypertensive medications and cancer is complex and requires further investigation.
- Awareness of study discrepancies, including drug classes and patient characteristics, is crucial.
- Further research is needed to elucidate the precise effects and mechanisms.
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