Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

11.7K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.7K
Neuron Structure01:31

Neuron Structure

231.2K
Overview
231.2K
Neuron Structure01:30

Neuron Structure

18.1K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
18.1K
Internal Receptors01:31

Internal Receptors

74.6K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K
Conservation of Small Populations02:04

Conservation of Small Populations

17.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
What is Population Genetics?01:25

What is Population Genetics?

64.7K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RAEM: random-access electron microscopy for revisitable 3D imaging.

bioRxiv : the preprint server for biology·2026
Same author

Permeabilization with fenchone enhances cryopreservation of Drosophila embryos.

Biology letters·2026
Same author

The dynamic response of the bacterial flagellar motor to its direct intracellular input signal.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.

Nature communications·2026
Same author

The larval <i>Drosophila</i> mushroom body balances lateralized sensing and interhemispheric integration.

bioRxiv : the preprint server for biology·2026
Same author

SmartEM: machine learning-guided electron microscopy.

Nature methods·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

Odorant-induced Responses Recorded from Olfactory Receptor Neurons using the Suction Pipette Technique
08:08

Odorant-induced Responses Recorded from Olfactory Receptor Neurons using the Suction Pipette Technique

Published on: April 5, 2012

11.2K

Structured Odorant Response Patterns across a Complete Olfactory Receptor Neuron Population.

Guangwei Si1, Jessleen K Kanwal2, Yu Hu3

  • 1Department of Physics, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

Neuron
|January 27, 2019
PubMed
Summary
This summary is machine-generated.

Understanding how olfactory receptor neurons (ORNs) process odor concentration is key. This study reveals shared individual and population patterns in ORN activity that structure odor perception in Drosophila larvae.

Keywords:
Drosophilacalcium imagingcombinatorial olfactory codedose response relationshipmicrofluidicsmolecular recognitionolfactory receptor neuronspower lab distributionreceptor sensitivitytemporal filter

More Related Videos

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
10:16

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

Published on: July 13, 2015

27.4K
Tracking Drosophila Larval Behavior in Response to Optogenetic Stimulation of Olfactory Neurons
06:49

Tracking Drosophila Larval Behavior in Response to Optogenetic Stimulation of Olfactory Neurons

Published on: March 21, 2018

7.8K

Related Experiment Videos

Last Updated: Jan 30, 2026

Odorant-induced Responses Recorded from Olfactory Receptor Neurons using the Suction Pipette Technique
08:08

Odorant-induced Responses Recorded from Olfactory Receptor Neurons using the Suction Pipette Technique

Published on: April 5, 2012

11.2K
Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
10:16

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

Published on: July 13, 2015

27.4K
Tracking Drosophila Larval Behavior in Response to Optogenetic Stimulation of Olfactory Neurons
06:49

Tracking Drosophila Larval Behavior in Response to Optogenetic Stimulation of Olfactory Neurons

Published on: March 21, 2018

7.8K

Area of Science:

  • Neuroscience
  • Olfactory system research
  • Animal behavior

Background:

  • Odor perception involves distinguishing odors, recognizing them across concentrations, and detecting concentration changes.
  • The precise mechanisms by which olfactory receptor neuron (ORN) activity patterns support these functions are not fully understood.

Purpose of the Study:

  • To investigate how the complete ORN population in Drosophila larvae encodes odor information across varying concentrations.
  • To uncover shared individual- and population-level activity patterns that contribute to odor perception.

Main Methods:

  • Interrogated the complete ORN population in Drosophila larvae.
  • Sampled a wide range of odorants at different concentrations.
  • Analyzed ORN activity patterns at individual and population levels.

Main Results:

  • Each ORN's activity scales with odorant concentration via a fixed dose-response function with variable sensitivity.
  • ORN sensitivities across odorants and neurons follow a power-law distribution.
  • A single molecular geometrical property largely explains receptor sensitivity to odorants.
  • Similar temporal response filter shapes across odorants and ORNs extend findings to fluctuating environments.

Conclusions:

  • Identified shared individual- and population-level patterns in ORN activity.
  • These patterns provide a structural basis for odor perception, enabling discrimination, recognition, and concentration detection.
  • Findings advance our understanding of the fundamental principles governing olfactory processing.