Related Experiment Video

Updated: Jan 30, 2026

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse
06:04

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

8.1K

Effect of quercetin on the echocardiographic parameters of left ventricular diastolic function in patients with gout

Vitalii E Kondratiuk1, Yuliia P Synytsia1

  • 1Propedeutic Internal Medicine Department 2, Bogomolets National Medical University, Kyiv, Ukraine.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|January 27, 2019
PubMed

Insights

Quercetin supplementation improved cardiac diastolic function in men with gout and essential hypertension. This treatment also enhanced uric acid levels, kidney function, and blood pressure control over 12 months.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Disorders

Background:

  • Gout is linked to increased cardiovascular disease risk, including heart failure.
  • Essential hypertension (EH) is a common comorbidity in gout patients.
  • Left ventricular diastolic dysfunction is a significant predictor of cardiovascular events.

Purpose of the Study:

  • To evaluate the effect of quercetin on echocardiographic parameters of left ventricular diastolic function in patients with gout and EH.
  • To assess the impact of quercetin on purine metabolism, renal function, and blood pressure control.

Main Methods:

  • A randomized controlled trial involving 84 male patients with gout and EH.
  • The main group (43 patients) received quercetin in addition to standard treatment.
  • The comparative group (41 patients) received standard treatment without quercetin.
  • Echocardiographic parameters, uric acid levels, renal function (glomerular filtration rate), and blood pressure were monitored over 12 months.

Main Results:

  • Quercetin significantly improved echocardiographic parameters of diastolic function, including E/e' and left ventricular mass index.
  • Patients receiving quercetin achieved target uric acid levels faster and showed a greater reduction (33.7%).
  • Quercetin supplementation led to a 13.3% increase in glomerular filtration rate and a cumulative antihypertensive effect (5.5% reduction in systolic BP, 3.6% in diastolic BP).

Conclusions:

  • Adding quercetin to antihypertensive and urate-lowering therapy improves left ventricular diastolic function in patients with gout and EH.
  • Quercetin positively impacts purine metabolism, renal function, and blood pressure.
  • Quercetin offers a protective effect on cardiac diastolic function and contributes to overall cardiovascular health in this patient population.
Abstract

Keywords:
essential hypertensiongoutleft ventricular diastolic dysfunctionquercetin

More Related Videos

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

3.7K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

4.7K

Related Concept Videos

Compounds Essential to Human Function01:25

Compounds Essential to Human Function

The human body is composed of cells that are fundamentally made up of several different molecules. These molecules are essential to carry out all physiological processes in the body and are broadly classified into organic and inorganic based on their chemical structures.
Inorganic Compounds Essential to Human Functioning
Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic, i.e., they do not have a carbon-hydrogen bond. Water...
10.1K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.4K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
858
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
931
Wave Parameters01:10

Wave Parameters

The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.3K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
424