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Updated: Nov 17, 2025

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
INFLUENCE OF ADVERSE PRODUCTION FACTORS ON CEREBRAL HEMODYNAMIC IN LOCOMOTIVE DRIVERS
Olha M Arustamian1, Volodymyr S Tkachyshyn1, Vitalii E Kondratiuk1
1BOGOMOLET´S NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.
Objective:
The aim: To investigate the pathological changes in intra- and extra cranial blood vessels in workers of locomotive crews depending on their length of service.
Patients And Methods:
Materials and methods: The study involved 249 male patients, aged from 21 to 60 years who worked as locomotive drivers. We used Doppler examination and studied Doppler Indexes of cerebral vessels.
Results:
Results: Results of examination showed that with increasing length of work of workers of locomotive crews (together with increasing of their age) we have established: 1) Reduction the elasticity of blood vessels (77.6% of the patients); 2) Increased violation of venous circulation (86.4%); 3) Reduced blood flow in the basilar artery (64%); 4) Reduced blood flow in the right and left vertebral arteries (65.6% and 65.5% respectively); 5) Increase in the thickness of intimate / media complex more than 1.1 in 62 % of drivers. All of that also connected with length of their work.
Conclusion:
Conclusions: we founded that speed of blood flow and elasticity in intra- and extra cranial vessels reduced with increase the length of service of workers of locomotive crews. Also we received such results: increasing violation of venous circulation, reducing blood flow in the basilar artery and reducing of blood flow in right and left vertebral arteries, increase intima / media thicknesses greater than 1,1 in locomotive drivers.

