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[Regional mucocutaneous plasmacytosis].
E Bartolo1, P Cachäo, L Garcia e Silva
1Serviço de Dermatologia e Venerologia, Hospital de Santa Maria, Lisboa, Portugal.
Medicina Cutanea Ibero-Latino-Americana
|January 1, 1988
Summary
This study reports a rare case of chronic mucocutaneous plasma cell infiltration in a 48-year-old woman, presenting with nasal, facial, and endotracheal masses. Treatment with cobalt-therapy effectively reduced airway masses, suggesting a potentially benign condition.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- A 48-year-old woman presented with a rare condition characterized by confluent nodules on the nose and infraorbital areas, facial lesions, and endotracheal masses causing severe lumen reduction.
Observation:
- Histological examination revealed infiltration of the dermis and tracheal mucosa by normal-looking plasma cells.
- Laboratory findings included an elevated erythrocyte sedimentation rate (ESR) and polyclonal gammopathy, but no evidence of skeletal involvement, bone marrow infiltration, or Bence Jones proteinuria.
Findings:
- Cobalt-therapy demonstrated rapid efficacy in reducing endotracheal masses.
- Skin lesions were refractory to roentgen-therapy and multiple chemotherapeutic regimens.
- Laboratory values normalized, and the patient maintained a satisfactory general condition for two years.
Implications:
- The condition was differentiated from multiple myeloma and extramedullary plasmacytoma.
- The case was classified as a chronic, likely benign, mucocutaneous plasma cell infiltration.
- This case highlights the importance of considering benign plasma cell infiltrations in the differential diagnosis of mucocutaneous and airway masses.