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Updated: Jan 30, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical
Jean-Philippe Bastard1, Soraya Fellahi1, Axel Regeniter2
1AP-HP, UF Biomarqueurs Inflammatoires et Métaboliques, Service de Biochimie et Hormonologie, Hôpital Tenon, Paris, France; Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_938, CDR-Saint-Antoine, DHU i2B, IHU ICAN, Paris, France.
Abstract:
The qualitative evaluation of proteinuria represents a crucial diagnostic step in clinical practice for the classification of renal diseases according to glomerular, tubulo-interstitial, mixed injury or related to monoclonal gammopathy. Combined with the quantitative evaluation, it also allows an assessment of the disease's severity and prognosis as well as the response to treatment. The development of the urine protein profile (UPP) combines specific urine protein assays on a urine spot analyzing glomerular protein markers such as albumin, transferrin and immunoglobulin G, and tubular markers such as alpha-1microglobulin and retinol binding protein, to generate a detailed quantitative and qualitative proteinuria assessment. This short overview proposes to illustrate the diagnostic and prognostic usefulness of UPP in different common clinical situations.
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