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Updated: Jan 30, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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Signal transduction pathways and resistance to targeted therapies in glioma

Arata Tomiyama1, Koichi Ichimura2

  • 1Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

Seminars in Cancer Biology
|January 28, 2019
PubMed

Insights

Glioblastoma treatment remains poor due to resistant residual tumors. Understanding molecular networks offers new therapeutic targets for refractory gliomas, improving patient outcomes.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma (GBM) treatment outcomes remain poor despite advances in surgery and adjuvant therapies.
  • Limited tumor resection and residual tumor resistance to radiation and chemotherapy contribute to poor prognosis.
  • Novel therapeutic strategies are urgently needed to overcome treatment resistance in gliomas.

Purpose of the Study:

  • To review current understanding of molecular networks governing glioma biology.
  • To focus on how intracellular signaling molecules in gliomas contribute to therapeutic resistance.
  • To identify potential novel therapeutic targets against refractory gliomas.

Main Methods:

  • Review of recent large cohort studies on genetic alterations in glioblastoma.
  • Analysis of evidence on molecular networks and intracellular signaling pathways in gliomas.
  • Focus on the association between signaling molecules and resistance to current therapies.

Main Results:

  • Genetic information and intracellular molecular signaling are networked in gliomas.
  • Specific molecules and signaling pathways play essential roles in resistance to radiation and chemotherapy.
  • These networks offer insights into the mechanisms of refractoriness in gliomas.

Conclusions:

  • Understanding molecular networks is crucial for developing effective glioma treatments.
  • Targeting specific intracellular signaling molecules may overcome resistance to current therapies.
  • This knowledge can lead to novel therapeutic strategies for refractory glioblastoma.
Keywords:
GliomaResistance to therapySignal transduction

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