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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Potential Energy00:52

Potential Energy

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The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
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Potential Energy01:09

Potential Energy

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A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
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Subviral Agents01:29

Subviral Agents

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Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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Standard Electrode Potentials03:02

Standard Electrode Potentials

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On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
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Cell Potential and Free Energy02:58

Cell Potential and Free Energy

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Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
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MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Peptides as Potential Anticancer Agents.

Shams Aaghaz1, Vivek Gohel2, Ahmed Kamal3

  • 1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S Nagar, Mohali, India.

Current Topics in Medicinal Chemistry
|January 29, 2019
PubMed
Summary
This summary is machine-generated.

Natural bioactive peptides show promise as anticancer agents by targeting tumor cells. Further research is needed to overcome challenges in delivery, toxicity, and production for effective cancer therapy.

Keywords:
ApoptosisCancerEpigeneticsMarineOncogenePeptide.

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Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Cancer is a complex disease with heterogeneous cell subpopulations developing resistance to therapies.
  • Diverse cancer subtypes necessitate tailored therapeutic interventions, often requiring combination treatments.
  • Natural compounds, particularly bioactive peptides, offer a promising avenue for anticancer drug development due to their mechanisms of action.

Purpose of the Study:

  • To review natural peptides that specifically target tumor cells for anticancer therapy.
  • To highlight the potential of these peptides as less toxic alternatives to conventional treatments.
  • To discuss challenges and recent advancements in the development of anticancer peptides (ACPs).

Main Methods:

  • Literature review of studies on natural bioactive peptides with anticancer properties.
  • Analysis of peptide mechanisms targeting tumor cells and their resistance phenotypes.
  • Evaluation of challenges in anticancer peptide (ACP) development, including delivery, toxicity, and stability.

Main Results:

  • Bioactive peptides from natural sources demonstrate potential in targeting tumor cells and overcoming resistance.
  • Peptides can modulate DNA repair, gene expression, and epigenetic mechanisms relevant to cancer.
  • Recent research explores peptides as adjuvants to established anticancer drugs.

Conclusions:

  • Natural peptides represent a promising class of anticancer agents with improved tumor-specific targeting and reduced toxicity.
  • Overcoming challenges in delivery, cost, selectivity, and stability is crucial for advancing peptide-based cancer therapeutics.
  • Further preclinical and clinical studies are warranted to fully realize the therapeutic potential of these natural compounds.