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Related Concept Videos

Protein Families02:47

Protein Families

16.8K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Protein Families02:47

Protein Families

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Gene Families01:57

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Gene Families01:57

Gene Families

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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Patterns of Fever01:26

Patterns of Fever

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Before understanding the types and patterns of fever, it is essential to know its phases.
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Related Experiment Video

Updated: Jan 30, 2026

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues
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Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

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Familial Mediterranean Fever.

Huri Ozdogan1, Serdal Ugurlu1

  • 1University of Istanbul-Cerrahpasa, Cerrahpasa Medical Faculty, Division of Rheumatology, Department of Internal Medicine, 34098 Istanbul, Turkey.

Presse Medicale (Paris, France : 1983)
|January 29, 2019
PubMed
Summary

Familial Mediterranean Fever (FMF) is a common autoinflammatory disorder. Treatment with colchicine is standard, with anti-IL-1 agents used for refractory cases to prevent amyloidosis.

Area of Science:

  • Genetics and Immunology
  • Autoinflammatory Diseases

Background:

  • Familial Mediterranean Fever (FMF) is a prevalent hereditary periodic fever syndrome, primarily affecting Mediterranean populations but increasingly recognized globally.
  • It is an autosomal recessive autoinflammatory disease linked to mutations in the MEFV gene, encoding pyrin, a regulator of IL-1β-mediated inflammation.

Purpose of the Study:

  • To provide an overview of Familial Mediterranean Fever (FMF), including its genetic basis, clinical presentation, and management strategies.
  • To highlight the role of pyrin and IL-1β in FMF pathogenesis and discuss diagnostic challenges related to genetic mutations.

Main Methods:

  • Clinical diagnosis based on characteristic self-limited bouts of fever and serositis.
  • Genetic analysis focusing on MEFV gene mutations, acknowledging cases with single or no mutations.

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  • Review of current treatment protocols and emerging therapies.

    • Main Results:

    • FMF is characterized by recurrent fever and serositis, with AA amyloidosis as a major long-term complication.
    • MEFV gene mutations, particularly those affecting pyrin function, are central to FMF pathogenesis.
    • Colchicine is the primary treatment, effectively preventing febrile attacks and amyloidosis in most patients.

    Conclusions:

    • Familial Mediterranean Fever (FMF) requires lifelong management, primarily with colchicine, to mitigate disease activity and prevent severe complications like amyloidosis.
    • Anti-IL-1 agents offer an alternative for patients unresponsive to colchicine, underscoring the importance of targeted inflammation control.