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Updated: Jan 30, 2026
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Health-Promoting Strategies for the Aging Brain
Stephen T Chen1, Dax Volle1, Jason Jalil1
1Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles; the University of California, Los Angeles, Longevity Center, Los Angeles; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles.
Cognitive decline in aging is not inevitable. This review highlights modifiable risk factors and interventions to promote brain health and prevent dementia, emphasizing public health strategies for an aging population.
Area of Science:
- Neuroscience
- Gerontology
- Public Health
Background:
- Global population aging presents significant challenges to brain health.
- Increased longevity is associated with age-related diseases impacting cognitive function.
- While some cognitive decline is typical with aging, severe decline and dementia are not inevitable.
Purpose of the Study:
- To review evidence on factors influencing cognitive decline in aging.
- To identify interventions that may mitigate or prevent age-related cognitive dysfunction and dementia.
- To advocate for public health initiatives to promote brain health in older adults.
Main Methods:
- Literature review of conditions and risk factors for cognitive decline.
- Synthesis of evidence on interventions for mitigating cognitive aging.
- Analysis of public health strategies for brain health promotion.
Main Results:
- Identified numerous risk factors contributing to cognitive decline and dementia.
- Presented evidence supporting interventions to modify the course of brain aging.
- Highlighted the potential for prevention and mitigation of cognitive sequelae.
Conclusions:
- The trajectory of age-related brain disease and dysfunction can be modified.
- Promising strategies exist to promote brain health and prevent cognitive decline.
- A robust public health effort is crucial for implementing these strategies effectively.
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