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Published on: February 17, 2023
Discovery of meta-Amido Bromophenols as New Antitubercular Agents
Jie Liang1, Yun-Xiang Tang2,3, Xiang-Zheng Tang1
1School of Pharmaceutical Sciences, Sun Yat-sen University.
Abstract:
A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains. The compounds did not show inhibitory activity against normal Gram-positive and Gram-negative bacteria. Moderate cytotoxicities and good metabolic stability were observed for the selected compounds. The results demonstrated meta-amido bromophenols as a new class of antitubercular agents with good potentials.
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