CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque

Area of Science:

• Dermatopathology
• Oncodermatology

Background:

• Lymphomatoid papulosis (LyP) is a rare primary cutaneous CD30-positive lymphoproliferative disorder.
• Type E LyP is characterized by angioinvasion and angiodestruction, with CD30+ and CD8+ lymphocyte infiltration.
• While LyP can co-occur with mycosis fungoides, LyP type E developing from parapsoriasis en plaque is not previously reported in English literature.

Observation:

• A case of angioinvasive LyP (type E) developing from parapsoriasis en plaque was observed.
• The patient's condition exhibited characteristic angiocentric and angiodestructive features.
• Immunohistochemical staining was utilized to investigate the underlying pathomechanisms.

Findings:

• The study describes the first reported instance of LyP type E arising from parapsoriasis en plaque.
• Immunohistochemical analysis provided insights into the pathomechanisms of this rare presentation.
• The findings contribute to understanding the spectrum of LyP and its potential evolution.

Implications:

• This case expands the known clinical spectrum of lymphomatoid papulosis.
• It underscores the importance of considering LyP type E in cases of parapsoriasis en plaque with concerning features.
• Further research into the pathogenesis of LyP evolving from precursor lesions is warranted.