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Updated: Jan 30, 2026

Protein Complex Affinity Capture from Cryomilled Mammalian Cells
Published on: December 9, 2016
Photo-induced formation of organic nanoparticles possessing enhanced affinities for complexing nerve agent mimics
Sarah E Border1, Radoslav Z Pavlović, Lei Zhiquan
1Department of Chemistry & Biochemistry, The Ohio State University, 100 West 18th Avenue, 43210 Columbus, Ohio, USA. badjic.1@osu.edu.
Abstract:
Molecular baskets 16--36-, functionalized with α-amino acids at their rim, undergo photo-induced α-decarboxylations to give amphiphilic 43--63- assembling into nanoparticles. Nanoparticulate 43--63- possess greater affinities for complexing OPs (akin to sarin and cyclosarin) than monomeric 16--36-. With the ability of nanoparticles to function in urine, our study sets the stage for creating novel nanocarriers capable of spatiotemporal sequestration of nerve agents or pesticides in competitive chemical environments.
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