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Reducing the stigma of long acting injectable antipsychotics - current concepts and future developments
David M Taylor1,2, Sitaram Velaga3, Ursula Werneke4
1a Pharmacy Department Denmark Hill , Maudsley Hospital , London , UK.
Nordic Journal of Psychiatry
|January 29, 2019
Summary
Long-acting injectable antipsychotics (LAI-APs) improve adherence and outcomes but face skepticism. Addressing stigma and improving administration are key to wider LAI-AP adoption in psychiatric care.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Long-acting injectable antipsychotics (LAI-APs) represent a significant advancement in psychiatric treatment, particularly for improving patient adherence and clinical outcomes.
- Despite their benefits, both healthcare providers and patients often harbor skepticism regarding their use.
Purpose of the Study:
- To elucidate the rationale behind the utilization of LAI-APs.
- To critically review the established effectiveness of LAI-APs.
- To explore the barriers hindering the broader adoption of LAI-APs in clinical practice.
Main Methods:
- A comprehensive clinical overview of LAI-APs was conducted.
- Perspectives from both patients and physicians were considered.
Main Results:
- LAI-APs are designed to enhance treatment adherence, potentially reducing relapse and hospitalization rates.
- Current evidence supporting LAI-APs' effectiveness is limited, with meta-analyses showing weak results.
- Stigma and concerns about coercion are significant barriers for both patients and clinicians.
- Strategies to improve adherence include strengthening the therapeutic relationship, enhancing patient information, minimizing adverse effects, and developing longer-acting formulations.
- Future innovations may involve needle-free administration methods.
Conclusions:
- Enhancing drug adherence is a primary objective for clinicians and pharmaceutical developers aiming to improve patient outcomes in psychiatric care.
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