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Updated: Jan 30, 2026
05:06
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
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[New Systemic Therapies for Advanced Hepatocellular Carcinoma]
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|January 29, 2019
Summary
New systemic therapies, including regorafenib, lenvatinib, cabozantinib, and ramucirumab, show promise for advanced hepatocellular carcinoma (HCC) patients. These treatments offer improved survival options for those with HCC, particularly after sorafenib failure.
Area of Science:
- Hepatocellular Carcinoma Research
- Oncology Drug Development
- Clinical Trial Analysis
Background:
- Sorafenib, approved in 2007, was the primary systemic therapy for advanced HCC.
- Many subsequent drugs failed in first- and second-line settings, highlighting an unmet need.
- Recent advancements have introduced new effective therapies between 2017-2018.
Purpose of the Study:
- To review novel systemic therapies for advanced hepatocellular carcinoma (HCC).
- To summarize the efficacy and tolerability of recently approved drugs.
- To discuss the role of tyrosine kinase inhibitors, monoclonal antibodies, and immune checkpoint inhibitors in HCC treatment.
Main Methods:
- Review of phase III clinical trials for regorafenib, lenvatinib, cabozantinib, and ramucirumab.
- Analysis of treatment outcomes in first- and second-line settings for advanced HCC.
- Inclusion of data on immune-oncology drugs targeting PD-1/PD-L1.
Main Results:
- Regorafenib and cabozantinib demonstrated improved survival in patients progressing after sorafenib.
- Lenvatinib met non-inferior survival endpoints compared to sorafenib in treatment-naïve patients.
- Ramucirumab showed efficacy in patients with baseline AFP ≥400 ng/mL, establishing a biomarker-driven approach.
Conclusions:
- Several new systemic therapies, including TKIs and monoclonal antibodies, are now available for advanced HCC.
- These agents offer improved outcomes, particularly for patients who have progressed on or are ineligible for prior therapies.
- Immune checkpoint inhibitors represent a promising future direction in HCC treatment.
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