Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Therapeutic Index01:13

Therapeutic Index

6.8K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.4K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.4K
Therapeutic Communication01:30

Therapeutic Communication

8.0K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
8.0K
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

1.4K
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.4K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.1K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

1.9K
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Unraveling inflammatory pathways in sickle cell disease: molecular, cellular and translational insights.

Frontiers in immunology·2026
Same author

Anti-IL-18 immunotherapy decreases inflammatory and vaso-occlusive responses in mice with sickle cell disease.

Experimental hematology·2026
Same author

Caspase-1 activation drives vascular inflammatory processes and hypoperfusion in intravascular hemolysis.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Circulating Monocytes Contribute to Erythrocyte Clearance in Polycythemia Vera.

International journal of molecular sciences·2025
Same author

Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo.

British journal of haematology·2025
Same author

Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia.

Haematologica·2024

Related Experiment Video

Updated: Jan 30, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.4K

cGMP modulation therapeutics for sickle cell disease.

Nicola Conran1, Lidiane Torres1

  • 1Hematology Center, University of Campinas - UNICAMP, Cidade Universitária, Campinas-SP 13083-878-SP, Brazil.

Experimental Biology and Medicine (Maywood, N.J.)
|January 30, 2019
PubMed
Summary

Sickle cell disease (SCD) treatments are limited. Targeting cGMP pathways with specific drugs may offer new therapeutic options for SCD by reducing inflammation and improving fetal hemoglobin levels.

Keywords:
cGMPfetal hemoglobinhemolysishydroxyureanitric oxidephosphodiesterasessGC stimulatorssickle cell diseasesoluble guanylate cyclase

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.4K
Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model
06:19

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Published on: October 20, 2023

2.8K

Related Experiment Videos

Last Updated: Jan 30, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.4K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.4K
Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model
06:19

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model

Published on: October 20, 2023

2.8K

Area of Science:

  • Biochemistry
  • Hematology
  • Pharmacology

Background:

  • Sickle cell disease (SCD) is a common inherited disorder with severe health complications and reduced lifespan.
  • Current treatments for SCD, including stem cell transplant and hydroxyurea, have limitations.
  • Vaso-occlusive episodes are a hallmark of SCD, often necessitating hospitalization.

Purpose of the Study:

  • To review the role of intracellular cGMP-dependent signaling pathways in the pathophysiology of sickle cell disease.
  • To explore the potential of targeting these pathways for novel SCD therapeutics.
  • To highlight the therapeutic benefits of soluble guanylate cyclase (sGC) stimulators and phosphodiesterase (PDE) inhibitors.

Main Methods:

  • Literature review focusing on cGMP signaling in SCD.
  • Analysis of existing and potential therapeutic strategies targeting sGC and PDEs.
  • Examination of the impact of these pathways on vasorelaxation, inflammation, and fetal hemoglobin production.

Main Results:

  • Intracellular cGMP signaling pathways play a critical role in SCD pathophysiology.
  • Modulation of cGMP pathways can lead to vasorelaxation and anti-inflammatory effects.
  • Targeting sGC stimulators or PDE inhibitors may increase anti-sickling fetal hemoglobin levels.

Conclusions:

  • Targeting cGMP-dependent signaling pathways represents a promising therapeutic strategy for sickle cell disease.
  • sGC stimulators and PDE inhibitors offer potential for vasorelaxation, reduced inflammation, and increased fetal hemoglobin.
  • Further research into these pathways could lead to improved treatments for SCD patients.