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Updated: Jan 30, 2026

Method to Measure Tone of Axial and Proximal Muscle
Published on: December 14, 2011
Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma
Cynthia J Koziol-White1, Reynold A Panettieri2
1Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers Institute for Translational Medicine and Science, Rutgers University, State University of New Jersey, 89 French Street, Suite 4268, New Brunswick, NJ 08901, USA.
Abstract:
Airway smooth muscle is the primary cell mediating bronchomotor tone. The milieu created in the asthmatic lung modulates airway smooth muscle contractility and relaxation. Experimental findings suggest intrinsic abnormalities in airway smooth muscle derived from patients with asthma in comparison with airway smooth muscle from those without asthma. These changes to excitation-contraction pathways may underlie airway hyperresponsiveness and increased airway resistance associated with asthma.
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