Related Experiment Video
Updated: Jan 30, 2026

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol
Published on: April 4, 2018
[Invasive Micropapillary Carcinoma of the Colon That Was Difficult to Diagnose Preoperatively]
Naoto Mizumura1, Satoshi Okumura, Sho Toyoda
1Dept. of Surgery, Bellland General Hospital.
Abstract:
A 73-year-old man was admitted with sigmoid colon diverticulitis. Although a biopsy did not indicate malignancy, the sigmoid colon was completely obstructed following conservative treatment. After sigmoidectomy, the histopathological findings revealed a well-differentiated adenocarcinoma localized to the mucosal surface; invasive micropapillary carcinoma (IMPC)accounting for>95% of the tumor volume spread extensively below the submucosal layer. IMPC is highly malignant and difficult to diagnose preoperatively, possibly due to the presence of poorly differentiated histological sub-types in the deepest portions of the tumor.
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