Prognostic Factors in Colorectal Cancer Patients with Synchronous Peritoneal Metastasis Undergoing Macroscopic...

Area of Science:

• Oncology
• Surgical Oncology
• Gastroenterology

Background:

• Colorectal cancer (CRC) with synchronous peritoneal metastasis presents a significant prognostic challenge.
• Macroscopic complete resection is key for favorable outcomes, but prognostic factors remain unclear.
• Identifying these factors is crucial for optimizing care and predicting prognosis in CRC patients with peritoneal metastasis.

Purpose of the Study:

• To identify clinicopathological prognostic factors in patients with CRC and synchronous peritoneal metastasis undergoing macroscopic complete resection.
• To improve prognostic stratification and guide individualized management strategies for this high-risk population.

Main Methods:

• A prospective, multi-institutional cohort study.
• Inclusion of 36 patients with CRC and synchronous peritoneal metastasis who underwent macroscopic complete resection.
• Assessment of clinicopathological factors influencing prognosis.

Main Results:

• Recurrence occurred in 72% of patients, predominantly in the peritoneum.
• Low preoperative serum CA19-9 levels were associated with favorable overall survival (P=0.044).
• Right-sided CRC showed more favorable overall survival than left-sided CRC (P=0.047).
• Right-sided CRC with low CA19-9 demonstrated significantly better overall survival (P<0.001).

Conclusions:

• Recurrence is frequent in CRC patients with synchronous peritoneal metastasis post-resection.
• Tumor sidedness and serum CA19-9 levels are important prognostic indicators.
• Integrating these factors can enhance prognostic stratification and personalize management.