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Pattern of sleep dysfunction in systemic lupus erythematosus: a cluster analysis.
Domenico Paolo Emanuele Margiotta1, Alice Laudisio2, Luca Navarini3
1Unit of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, Campus Bio-Medico University of Rome, via Alvaro del Portillo 21, 00128, Rome, Italy.
Clinical Rheumatology
|January 30, 2019
Summary
This study identified three distinct sleep dysfunction clusters in Systemic Lupus Erythematosus (SLE) patients, revealing patterns in sleep latency and duration. These findings may help personalize treatments for SLE-related sleep disturbances.
Area of Science:
- Rheumatology
- Sleep Medicine
- Psychiatry
Background:
- Sleep dysfunction is common in Systemic Lupus Erythematosus (SLE) patients.
- Understanding the specific patterns of sleep disturbances is crucial for effective management.
Purpose of the Study:
- To investigate the clustering of various sleep dysfunction components in SLE patients.
- To identify distinct sleep profiles within the SLE population.
Main Methods:
- A cross-sectional study involving 79 SLE patients.
- Sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI).
- Hierarchical clustering used to define sleep clusters based on PSQI components; depression, anxiety, and quality of life were also measured.
Main Results:
- Three distinct sleep clusters were identified.
- Cluster 1 showed the best sleep quality, while Cluster 2 had increased sleep latency.
- Cluster 3 exhibited the worst sleep quality, with impaired sleep latency and duration, alongside higher depression and anxiety scores.
Conclusions:
- SLE patients can be stratified into three sleep dysfunction clusters based on latency, duration, and overall quality.
- Identifying these clusters may facilitate personalized therapeutic approaches for sleep disorders in SLE.
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