Related Experiment Video
Updated: Jan 30, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
Published on: August 15, 2020
Modelling and forecasting adult age-at-death distributions
Ugofilippo Basellini1,2, Carlo Giovanni Camarda1
1a Institut national d'études démographiques (INED).
Abstract:
Age-at-death distributions provide an informative description of the mortality pattern of a population but have generally been neglected for modelling and forecasting mortality. In this paper, we use the distribution of deaths to model and forecast adult mortality. Specifically, we introduce a relational model that relates a fixed 'standard' to a series of observed distributions by a transformation of the age axis. The proposed Segmented Transformation Age-at-death Distributions (STAD) model is parsimonious and efficient: using only three parameters, it captures and disentangles mortality developments in terms of shifting and compression dynamics. Additionally, mortality forecasts can be derived from parameter extrapolation using time-series models. We illustrate our method and compare it with the Lee-Carter model and variants for females in four high-longevity countries. We show that the STAD fits the observed mortality pattern very well, and that its forecasts are more accurate and optimistic than the Lee-Carter variants.
Related Concept Videos
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Adult Stem Cells
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Drug Distribution: Volume of Distribution
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...

