[Effect of anti-inflammatory preparations on the osteoinductive activity of bone tissue]

The effects of steroid (dexamethasone) and nonsteroid (indomethacin) anti-inflammatory drugs on the composition and the osteoinductive activity of bone tissue were studied on rats. Dexamethasone was found to induce bone tissue demineralisation and dose-dependent suppression of the osteoinductive activity, i.e. the ability to cause ectopic osteogenesis. Indomethacin, on the contrary, increases the osteoinductive activity of bone tissue. The findings are suggested to be due to different effect of steroid and nonsteroid anti-inflammatory drugs on the synthesis of prostaglandins and leukotrienes.