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Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence
Eusebio Real1,2, José Manuel Icardo3, Gaspar Fernández-Barreras4
1Photonics Engineering Group, Department TEISA, University of Cantabria, 39005 Santander, Spain. eusebio.real@unican.es.
Sensors (Basel, Switzerland)
|January 31, 2019
Summary
Polarization Sensitive Optical Coherence Tomography (PS-OCT) can identify mitral valve chordae tendineae (CTs) degradation by measuring reduced birefringence. This optical property serves as a diagnostic marker for guiding heart valve surgery.
Area of Science:
- Biomedical Optics
- Cardiovascular Research
- Materials Science
Background:
- Mitral valve complex defects cause heart malfunction.
- Chordae tendineae (CTs) are crucial for valve leaflet support.
- Diseased CTs (rheumatic, degenerative) exhibit altered collagen structure.
Purpose of the Study:
- To assess Polarization Sensitive Optical Coherence Tomography (PS-OCT) for characterizing CTs.
- To quantify birefringence reduction in diseased human CTs.
- To propose birefringence as a diagnostic marker for intraoperative guidance.
Main Methods:
- Utilized PS-OCT to analyze collagen organization and birefringence in human CTs.
- Compared optical properties of healthy and pathologically affected CTs.
- Correlated birefringence changes with rheumatic and degenerative pathologies.
Main Results:
- PS-OCT effectively discriminated healthy from diseased CTs.
- Quantified significant birefringence reduction in degenerated and rheumatic CTs.
- Identified reduced birefringence as a reliable indicator of CT degradation.
Conclusions:
- Reduced birefringence in CTs is a hallmark of degenerative and rheumatic diseases.
- PS-OCT can accurately measure this optical property.
- Birefringence quantification via PS-OCT is a promising diagnostic marker for guiding mitral valve surgery.
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