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Compressed sensing-enabled phase-sensitive swept-source optical coherence tomography.

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    We developed a novel phase-sensitive swept-source optical coherence tomography (PhS-SS-OCT) system using Compressed Sensing (CS) for phase stabilization. This method significantly reduces data bandwidth while maintaining excellent phase stability for high-speed imaging.

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    Area of Science:

    • Biomedical Optics
    • Medical Imaging Technology
    • Optical Engineering

    Background:

    • Phase stabilization is crucial for quantitative analysis in swept-source optical coherence tomography (SS-OCT).
    • Conventional phase stabilization methods often require high data bandwidth, limiting real-time applications.
    • Compressed Sensing (CS) offers a promising approach for efficient data reconstruction.

    Purpose of the Study:

    • To introduce a novel phase-sensitive SS-OCT (PhS-SS-OCT) system.
    • To demonstrate a new method for phase stabilization using sub-sampled calibration signals reconstructed with CS theory.
    • To evaluate the system's performance in phase stability, data bandwidth reduction, and biological sample imaging.

    Main Methods:

    • Development of a PhS-SS-OCT system incorporating random sub-sampling of the calibration signal.
    • Mathematical investigation and computer simulations to validate the CS-based reconstruction method.
    • Experimental validation using phantom studies for vibrational frequency testing and flow velocity measurements.
    • In vivo imaging of blood flow in swine arteries.

    Main Results:

    • The CS-based reconstruction effectively stabilized phase information from sub-sampled calibration signals.
    • The proposed scheme achieved excellent phase stability with significantly reduced data bandwidth compared to conventional methods.
    • Successful detection of blood flow in ex vivo swine arteries was demonstrated.
    • The system exhibited compatibility with existing SS-OCT platforms.

    Conclusions:

    • The novel PhS-SS-OCT system with CS-based phase stabilization offers superior performance in phase stability and data bandwidth efficiency.
    • This approach is a viable and potentially preferred solution for future high-speed, phase-sensitive OCT applications.
    • The system's capability extends to real-world biological sample imaging, highlighting its practical utility.