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Updated: Jan 30, 2026

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
Published on: May 20, 2011
Why do patients with limb ischaemia present late to a vascular surgeon? A prospective cohort study from the
Amna Riaz Khan1, Fareed Ahmed Shaikh1, Asma Riaz1
1Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
Objective:
To look into the factors responsible for delay in presentation of Iimb ischemia patients to a vascular surgeon.
Methods:
The prospective cohort study was conducted at the Aga Khan University Hospital, Karachi, from October 01, 2016, to August 10, 2018. Patients coming with delayed presentation of both acute and chronic limb ischemia were included. All the patients were assessed by qualified vascular surgeons. SPSS 23 was used for data analysis.
Results:
Of the 55 patients, 33(60%) had acute and 22(40%) had chronic limb ischaemia. Mean age of acute cases was 44±23.72 years and it was 60±12.49 years for chronic cases. Overall, the commonest reason behind delay was non-referral by primary physician which was the case with 11(33.3%) patients in the acute group, and 13(59%) in the chronic group. The limb loss in the acute group was 20(60%) and 8(36%) in the chronic group..
Conclusion:
Delayed presentation of patients with limb ischaemia is mainly due to non-referral. A robust campaign needs to be launched to reduce the rate of limb loss.
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