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Bromocriptine in cocaine withdrawal--does it work?

D W Teller1, P Devenyi

  • 1Clinical Institute, Addiction Research Foundation, Toronto, Ontario, Canada.

The International Journal of the Addictions
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study investigated bromocriptine for cocaine withdrawal, finding no evidence of dopamine depletion and only slight improvements in craving, likely due to placebo effects.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Heavy cocaine use may cause dopamine depletion, leading to intense cravings post-withdrawal.
  • Bromocriptine, a dopamine agonist, was explored to mitigate cocaine relapse during withdrawal.

Purpose of the Study:

  • To assess the efficacy of bromocriptine in preventing relapse in heavy cocaine users.
  • To evaluate whether bromocriptine treatment indicates dopamine depletion during cocaine withdrawal.

Main Methods:

  • An uncontrolled trial involving 25 heavy cocaine users.
  • Measurement of serum prolactin levels before and after bromocriptine administration as a dopaminergic control indicator.
  • Utilizing an assessment scale to gauge craving and subjective discomfort.

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Main Results:

  • Serum prolactin levels did not indicate dopamine depletion following bromocriptine treatment.
  • A slight majority of patients (13/25) reported minor improvements in craving and discomfort.
  • Observed improvements were likely attributable to placebo effects rather than bromocriptine's pharmacological action.

Conclusions:

  • Bromocriptine treatment did not demonstrate a significant effect on dopamine depletion markers in heavy cocaine users.
  • The study suggests bromocriptine is not effective in reducing cocaine craving or withdrawal symptoms beyond a placebo response.
  • Further research with controlled trials is needed to clarify bromocriptine's role in cocaine dependence treatment.