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Related Experiment Videos

Deficiency of the insulin, glucose-mediated decrease in serum triglycerides in normolipidemic obese subjects.

R H Eckel1, C N Sadur, T J Yost

  • 1Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.

International Journal of Obesity
|January 1, 1988
PubMed
Summary
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Obese individuals show reduced triglyceride response to insulin and glucose infusions, indicating insulin resistance. This study highlights impaired lipid metabolism in obesity.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Lipid Metabolism

Background:

  • Obesity is associated with insulin resistance and altered lipid metabolism.
  • Understanding the impact of insulin on lipid profiles in obese individuals is crucial.

Purpose of the Study:

  • To compare the effects of insulin and glucose infusion on lipid metabolism in normolipidemic obese and control subjects.
  • To investigate potential differences in triglyceride and cholesterol responses to insulin in obesity.

Main Methods:

  • A 6-hour infusion of insulin and glucose was administered to 29 normolipidemic obese and 20 control subjects.
  • Serum triglycerides (TG), cholesterol, and high-density lipoprotein (HDL) cholesterol levels were measured before and after infusion.
  • Insulin doses of 40 or 120 mU/m2 per min were used.

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Main Results:

  • Serum triglyceride levels decreased more in control subjects (35 mg/dl) than in obese subjects (23 mg/dl) following insulin and glucose infusion (P < 0.001).
  • Changes in HDL cholesterol and overall cholesterol were similar between obese and control groups.
  • The reduction in free fatty acids was comparable in both groups, suggesting specific impairment in TG metabolism.

Conclusions:

  • Normolipidemic obese subjects exhibit diminished responsiveness of serum triglycerides to insulin and glucose infusion.
  • This finding supports the concept that impaired triglyceride metabolism is a manifestation of insulin resistance in obesity.