Related Experiment Video
Updated: Jan 30, 2026
ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
Published on: February 10, 2017
Esophageal intramural pseudodiverticulosis complicated with severe stricture requiring surgical resection
Yusuke Onozato1, Yu Sasaki2, Yasuhiko Abe1,3
1Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Abstract:
Esophageal intramural pseudodiverticulosis (EIPD) is an uncommon benign disorder leading to esophageal strictures. The etiology remains unknown; however, anti-fungal treatments or endoscopic balloon dilation can improve early esophageal strictures and these rarely require surgical treatment. We report a case of a 46-year-old male with a 6 cm-long esophageal stricture due to EIPD, which did not improve following treatment with an anti-fungal agent, eventually causing aspiration pneumonia. Therefore, we performed a thoraco-laparoscopic esophagectomy, and his symptoms were improved after surgery. This case suggests that a surgical treatment should be considered in patients with extensive, severe strictures attributable to EIPD.
Insights
Esophageal intramural pseudodiverticulosis (EIPD) can cause severe strictures. Surgical intervention may be necessary for extensive EIPD strictures unresponsive to standard treatments.
Area of Science:
- Gastroenterology
- Surgical Oncology
Background:
- Esophageal intramural pseudodiverticulosis (EIPD) is a rare condition characterized by submucosal gland duct dilation, often leading to esophageal strictures.
- While typically benign and responsive to conservative management like antifungal therapy or endoscopic dilation, EIPD can occasionally present with severe, refractory strictures.
Observation:
- A 46-year-old male presented with a significant 6 cm esophageal stricture attributed to EIPD.
- Initial treatment with antifungal medication proved ineffective in alleviating the stricture.
- The patient subsequently developed aspiration pneumonia secondary to the unresolved esophageal stricture.
Findings:
- The patient underwent a thoraco-laparoscopic esophagectomy for the extensive EIPD-induced esophageal stricture.
- Post-surgical recovery demonstrated significant improvement in the patient's symptoms.
Implications:
- This case highlights that surgical management, such as esophagectomy, should be considered for patients with extensive and severe esophageal strictures caused by EIPD.
- It underscores the importance of considering surgical options when conservative and endoscopic treatments fail to resolve EIPD-related complications.
Related Concept Videos
01:30Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
01:26Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
01:26Requirements for Human Life
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
01:24Esophageal Varices-I: Introduction
01:24Hemodialysis II: Procedure and Complications
01:22Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....