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A Hybrid Experimental-Computational Modeling Framework for Cardiovascular Device Testing.

Ethan Kung^1,2, Masoud Farahmand³, Akash Gupta⁴

¹Department of Mechanical Engineering,Clemson University,Clemson, SC 29634.

Journal of Biomechanical Engineering

|January 31, 2019

Summary

This summary is machine-generated.

We developed a novel hybrid modeling framework, physiology simulation coupled experiment (PSCOPE), integrating computational simulations and experimental platforms. PSCOPE accurately models complex physiological scenarios and enables physical testing of medical devices with simulated feedback.

Keywords:

bench top hardware-in-the-loop hybrid medical device mock loop numerical ventricular assist device verification

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Area of Science:

Biomedical Engineering
Computational Biology
Physiological Modeling

Background:

Biomedical advances often require sophisticated computational and experimental modeling.
Integrating these platforms presents a significant challenge in developing comprehensive research tools.

Purpose of the Study:

To introduce a hybrid framework, physiology simulation coupled experiment (PSCOPE), merging in vitro experimental setups with computational simulations.
To validate PSCOPE's accuracy and demonstrate its utility in modeling complex cardiovascular scenarios.

Main Methods:

PSCOPE employs an iterative approach to couple an in vitro mock circuit with a lumped-parameter physiological simulation, establishing closed-loop feedback.
The framework was validated by comparing PSCOPE's Fontan graft obstruction models against established computational fluid dynamics methods.
An application involving a Jarvik 2000 blood pump in single-ventricle circulation was modeled to assess its performance.

Main Results:

PSCOPE demonstrated high fidelity, with normalized root-mean-square errors between 0.1% and 2.1% when modeling Fontan graft obstruction.
The framework successfully simulated the implantation of a Jarvik 2000 blood pump, showing potential for augmenting cardiac output by approximately 20% while maintaining safe blood pressures.
The study confirmed PSCOPE's capability to test medical devices within a simulated physiological environment.

Conclusions:

PSCOPE offers a validated, unified modeling framework that combines experimental and computational approaches for physiological research.
This hybrid model provides a powerful tool for the physical testing of medical devices, offering simulated physiological feedback for enhanced device evaluation.
PSCOPE advances the integration of in vitro experiments and computational modeling for complex biomedical applications, particularly in cardiovascular research.