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Lethal Alleles

Lethal Alleles

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Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...

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Leveraging Micro-CT Scanning to Analyze Parasitic Plant-Host Interactions

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The reassuring CT scan with a lethal diagnosis.

Ian Y Goh¹, Shuangli Wang¹, Mark Ray²

¹General Surgery, Greenslopes Private Hospital, Greenslopes, Queensland, Australia.

BMJ Case Reports

|February 1, 2019

Summary

A patient with a known abdominal aortic aneurysm experienced worsening back pain, highlighting a potential link between aortic issues and chronic pain. This case emphasizes the need for thorough evaluation in such scenarios.

Keywords:

emergency medicine general surgery vascular surgery

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Area of Science:

Vascular Surgery
Pain Management

Background:

Abdominal aortic aneurysm (AAA) is a serious vascular condition.
Chronic back pain is a common and often complex condition.

Observation:

A patient with a history of AAA presented with new-onset, worsening chronic back pain.
The back pain was localized and severe, prompting further investigation.

Findings:

Diagnostic imaging revealed a complication related to the abdominal aortic aneurysm.
The patient's symptoms were directly attributed to the vascular pathology.

Implications:

This case underscores the importance of considering AAA complications in patients with unexplained or worsening back pain.
Early recognition and management of AAA-related pain can prevent severe outcomes.
Highlights the intersection of vascular disease and chronic pain syndromes.