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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Chronic kidney disease as a multidisciplinary problem of contemporary medicine

V I Podzolkov1, A E Bragina1

  • 1I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Terapevticheskii Arkhiv
|February 1, 2019
PubMed

Insights

Chronic kidney disease (CKD) affects nearly half of hypertensive patients in Russia. Early screening and interventions, like irbesartan, are vital for managing CKD and preventing cardiovascular complications.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a significant health concern with a substantial impact on cardiovascular health.
  • Epidemiological data from Russia indicates high prevalence of CKD markers in hypertensive individuals (49.4%).
  • CKD shares common risk factors and pathogenetic mechanisms with hypertension, diabetes, and obesity.

Purpose of the Study:

  • To review the multifaceted problem of chronic kidney disease (CKD) from both nephrological and cardiological perspectives.
  • To highlight the relationship between the renal continuum and cardiovascular diseases.
  • To emphasize the importance of early detection and intervention in CKD management.

Main Methods:

  • Comprehensive literature review focusing on CKD epidemiology, risk factors, and pathogenesis.
  • Discussion of current classification and glomerular filtration rate (GFR) calculation methods.
  • Analysis of the renal continuum paradigm and its cardiovascular implications.

Main Results:

  • CKD is a major contributor to mortality, primarily through cardiovascular complications.
  • Hypertension, diabetes, and obesity are key drivers of CKD development and progression.
  • Nephroprotective effects of angiotensin receptor blocker II (irbesartan) demonstrated potential for intervention in varying CKD severity.

Conclusions:

  • Screening for renal dysfunction is necessary and justified due to the high prevalence and severe consequences of CKD.
  • Understanding the renal continuum is crucial for managing patients at risk of cardiovascular events.
  • Pharmacological interventions, such as irbesartan, show promise in mitigating CKD progression and associated cardiovascular risks.

Keywords:
angiotensin II receptor blockerschronic kidney diseasenephroprotectionrenal continuum

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