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Updated: Jan 30, 2026

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
Published on: October 2, 2014
[Therapeutic pathomorphosis in the practice of clinical cytologists.]
N M Zakharova1, O N Vetchinnikova2
1Medical Department of Federation Medical and Biology Agency, 142280, Moscow, Russian Federation.
Abstract:
Pathomorphosis means the changes that occur under the influence of various factors during the course of the disease. Therapeutic pathomorphosis develops during diagnostic and therapeutic procedures. The article considers the types of cellular reactions observed in the process of therapeutic pathomorphosis. The main cytological signs of destructive and proliferative processes for assessing the condition of the pathological focus, regardless of its location, are presented. The clinical significance of the study of cytological signs of therapeutic pathomorphosis is discussed.
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