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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
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Characterization of Baboon Cytomegalovirus Infection in Healthy Adult Baboons (Papio anubis)

Erin L Willis1, Taylor L Stevens2, Gary L White3

  • 1Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma.

Comparative Medicine
|February 2, 2019
PubMed

Insights

Baboon cytomegalovirus (BaCMV) infection is common in adult baboons, with higher DNA detection rates in older animals. Individual shedding rates remain consistent over time, informing conservation efforts.

Area of Science:

  • Veterinary Virology
  • Primate Immunology
  • Wildlife Health

Background:

  • Cytomegalovirus (CMV) is a widespread herpesvirus affecting humans and various mammalian species.
  • Chronic CMV infections can impact host immunity and pose risks, particularly to immunocompromised individuals and vulnerable wildlife populations.
  • Previous research indicated high CMV seropositivity in baboons (Papio anubis), with correlations to altered immune cell profiles.

Purpose of the Study:

  • To further characterize baboon cytomegalovirus (BaCMV) infection in healthy adult baboons.
  • To investigate the prevalence and shedding patterns of BaCMV in relation to age.
  • To assess the utility of commercially available anti-human CMV assays for detecting BaCMV antibodies in baboon serum.

Main Methods:

  • Analysis of blood samples from baboons aged 6 to 26 years for detectable BaCMV DNA.
  • Longitudinal monitoring of BaCMV shedding in saliva from individual baboons.
  • Evaluation of commercially available anti-human CMV IgG and IgM assays using baboon sera.

Main Results:

  • A low overall prevalence of detectable BaCMV DNA was observed, with increased detection rates in older baboons (over 15 years).
  • Individual baboons exhibited consistent rates of BaCMV recurrence and salivary shedding over time.
  • Several commercially available anti-human CMV assays showed potential for use with baboon sera.

Conclusions:

  • BaCMV infection dynamics in adult baboons are influenced by age, with older individuals showing higher viral DNA detection.
  • Consistent shedding patterns suggest stable BaCMV infection in individual baboons.
  • The findings enhance understanding of BaCMV and have implications for managing related viruses in other primate species.

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