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Non-uremic calciphylaxis associated with alcoholic hepatitis: A case report
Yasser M Sammour1, Haitham M Saleh2, Mohamed M Gad3
1Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, United States. sammouy@ccf.org.
World Journal of Hepatology
|February 2, 2019
Summary
Non-uremic calciphylaxis, a rare vascular condition, can manifest in patients with alcoholic liver disease. Treatment remains challenging, highlighting the need for further research into this severe condition.
Area of Science:
- Vascular Biology
- Nephrology
- Hepatology
Background:
- Calciphylaxis is a critical condition involving vascular calcification, typically linked to end-stage renal disease.
- Non-uremic calciphylaxis presents in patients without kidney disease, with diverse potential causes.
Observation:
- A case study details a morbidly obese 30-year-old female with alcoholic hepatitis presenting with painful calciphylaxis wounds.
- Hypercoagulability revealed low Protein C, low Antithrombin III, and positive lupus anticoagulant.
- Wound biopsy confirmed non-uremic calciphylaxis associated with alcoholic liver disease.
Findings:
- Standard treatment with Sodium Thiosulfate was ineffective for the patient's calciphylaxis wounds.
- The patient underwent debridement and broad-spectrum antibiotics for secondary infections.
- Despite interventions, the patient succumbed to sepsis and multiorgan failure.
Implications:
- This case underscores that non-uremic calciphylaxis can be associated with alcoholic liver disease.
- The optimal therapeutic strategy for non-uremic calciphylaxis remains undetermined.
- Further investigation is crucial for understanding and managing this severe condition.
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