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Developments beyond blood group serology in the genomics era
Catherine A Hyland1, Eileen V Roulis1, Elizna M Schoeman1
1Clinical Services and Research, Australian Red Cross Blood Service, Kelvin Grove, Queensland, Australia.
British Journal of Haematology
|February 2, 2019
Summary
Genomics is revolutionizing blood group serology by offering comprehensive coverage of blood group systems and antigen diversity. This genomic approach enhances transfusion management for improved patient compatibility.
Area of Science:
- Genomics and Transfusion Medicine
- Immunohaematology
- Bioinformatics
Background:
- Current blood group serology and genotyping platforms lack comprehensive coverage of all 36 blood group systems and population-specific antigen diversity.
- Existing methods are accurate but insufficient for fully characterizing complex blood group antigen profiles.
Purpose of the Study:
- To review the impact of genomics on blood group serology.
- To explore how genomic resources and technologies are transforming blood transfusion practices.
Main Methods:
- Bioinformatic data mining of large-scale whole genome and whole exome sequencing datasets.
- Laboratory investigations employing targeted sequencing approaches.
- Utilizing genomic resources such as the Human Reference Genome Sequence, curated blood group variant tables, and public genetic variant databases.
Main Results:
- Genomic studies provide accurate blood group predictions based on genome sequencing.
- These predictions have demonstrated utility in both research and reference laboratory settings.
- Genomics significantly expands the understanding of blood group antigen diversity across global populations.
Conclusions:
- Blood group genomics holds substantial potential to reshape donor and patient transfusion management strategies.
- The integration of genomics promises to facilitate more compatible blood transfusions.
- Genomic approaches offer a more comprehensive and accurate method for blood group determination.
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