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Myocardial injury in transient global amnesia: a case-control study
H Erdur1,2, B Siegerink3, R Ganeshan1
1Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin.
European Journal of Neurology
|February 2, 2019
Summary
Transient global amnesia (TGA) is linked to myocardial injury, with one in four patients showing elevated cardiac troponin. This brain-heart interaction warrants further study.
Area of Science:
- Neurology
- Cardiology
- Biomarkers
Background:
- Cardiac troponin (cTn) elevation is common in severe neurological disorders.
- Cardiac dysfunction has been anecdotally reported in transient global amnesia (TGA).
- Systematic assessment of myocardial injury in TGA was lacking.
Purpose of the Study:
- To systematically assess myocardial injury in patients with TGA.
- To compare the incidence of myocardial injury in TGA with other neurological conditions.
- To investigate potential brain-heart interactions in TGA.
Main Methods:
- A case-control study was conducted.
- 113 TGA patients were compared to migraine with aura, vestibular neuritis, and transient ischemic attack (TIA) groups.
- Myocardial injury was defined by elevated cTn (>99th percentile) using high-sensitivity assays.
Main Results:
- 25% of TGA patients (28/113) exhibited elevated cTn.
- TGA patients with cTn elevation were older, more often female, and had higher blood pressure.
- The odds of myocardial injury were significantly higher in TGA compared to all control groups, including TIA.
Conclusions:
- One in four TGA patients show evidence of myocardial injury.
- TGA is associated with a higher likelihood of myocardial injury than TIA.
- Findings suggest a TGA-related brain-heart interaction requiring further investigation.
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