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Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

102
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
102

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Related Experiment Video

Updated: Aug 11, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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New Cerebral Microbleeds After Catheter-Based Structural Heart Interventions: An Exploratory Analysis.

Tim Bastian Braemswig1,2,3,4, Madeleine Kusserow5,6, Barbara Bellmann7,8

  • 1Klinik und Hochschulambulanz für Neurologie Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.

Journal of the American Heart Association
|February 3, 2023
PubMed
Summary
This summary is machine-generated.

New cerebral microbleeds (CMBs) occur in 36% of patients after structural heart interventions like MitraClip procedures. Longer procedure times may increase the risk of these covert brain lesions.

Keywords:
catheter‐based structural heart interventionscerebral microbleedsleft atrial appendage closuremitral valve repair (MVR) using the MitraClip System

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Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Medical Imaging

Background:

  • Cerebral microbleeds (CMBs) are increasingly recognized as covert brain lesions.
  • CMBs indicate an elevated risk of future neurological events.
  • Data on CMBs in patients undergoing catheter-based structural heart interventions are limited.

Purpose of the Study:

  • To assess the occurrence of new cerebral microbleeds (CMBs).
  • To identify predictors of new CMBs in patients undergoing catheter-based structural heart interventions.
  • Focus on MitraClip procedures: left atrial appendage closure and percutaneous mitral valve repair.

Main Methods:

  • Exploratory analysis of 2 prospective, observational studies.
  • 47 patients underwent pre- and post-procedure cerebral MRI (3 Tesla) and cognitive tests.
  • Evaluated new CMBs after catheter-based left atrial appendage closure and percutaneous mitral valve repair.

Main Results:

  • New CMBs occurred in 17 of 47 patients (36%) post-intervention.
  • No significant difference in CMB occurrence between left atrial appendage closure and mitral valve repair.
  • Longer procedure time was associated with new CMBs, though attenuated after heparin adjustment.

Conclusions:

  • Approximately one-third of patients develop new CMBs after MitraClip procedures.
  • Longer procedural duration may be a risk factor for new CMBs.
  • Further research in larger populations is needed to clarify clinical relevance.