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Tumor budding in laryngeal carcinoma
Sumeyye Ekmekci1, Ulku Kucuk1, Seda Kokkoz1
1Department of Pathology, Health Sciences University, Tepecik Training and Research Hospital, Izmir, Turkey.
Indian Journal of Pathology & Microbiology
|February 2, 2019
Summary
Tumor budding, a measure of cancer cell clusters, is a significant prognostic factor in laryngeal squamous cell carcinoma. Its presence correlates with lymphovascular invasion, perineural invasion, and lymph node metastasis, indicating poorer outcomes.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Tumor budding, defined as small clusters of cancer cells at the invasive margin, is a recognized prognostic indicator in various cancers.
- Limited research exists on the prognostic significance of tumor budding specifically in laryngeal carcinomas.
Purpose of the Study:
- To investigate the prognostic significance of tumor budding in laryngeal squamous cell carcinoma (SCC).
- To correlate the presence and grade of tumor budding with clinicopathologic parameters and patient outcomes.
Main Methods:
- Retrospective analysis of 81 patients with laryngeal carcinoma treated between 2011 and 2016.
- Evaluation of clinicopathologic parameters, including tumor budding, lymphovascular invasion (LVI), perineural invasion (PNI), and lymph node metastasis (LNM).
Main Results:
- All 81 patients were diagnosed with squamous cell carcinoma (SCC).
- Tumor budding was observed in 62 cases (76.5%) and significantly correlated with LVI (P=0.017), PNI (P=0.012), and LNM (P=0.017).
- None of the non-budding cases exhibited LVI or PNI, and budding cases showed a higher rate of LNM (37% vs. 15%).
Conclusions:
- Tumor budding is a significant prognostic factor in laryngeal SCC.
- The presence of tumor budding is associated with adverse prognostic indicators such as LVI, PNI, and LNM.
- Further studies are warranted to fully elucidate the role of tumor budding in laryngeal cancer management.
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