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Updated: Jan 30, 2026

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres
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Transformable bubble-filled alginate microfibers via vertical microfluidics.

Ankur Shubhlal Chaurasia1, Shahriar Sajjadi

  • 1ESPCI Paris, 10 Rue Vauquelin, 75231, Paris cedex 05, Paris, France.

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Summary

Researchers developed a novel microfluidic setup to create transformable bubble-filled hydrogel microfibers. These fibers can be shaped and transformed into various structures, including micro-particles.

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Microfluidics

Background:

  • Hydrogel microfibers are versatile materials with applications in drug delivery and tissue engineering.
  • Fabrication of complex hydrogel structures with controlled morphology remains a challenge.

Purpose of the Study:

  • To develop a novel microfluidic method for fabricating transformable bubble-filled hydrogel microfibers.
  • To explore the transformation of these microfibers into diverse hydrogel structures and micro-particles.

Main Methods:

  • A buoyancy-assisted vertical microfluidic setup utilizing co-axial flow of sodium-alginate and air.
  • Injection into a calcium chloride solution for instantaneous gelation.
  • Controlled manipulation of gelation kinetics and buoyancy for fiber shaping and transformation.

Main Results:

  • Successfully fabricated bubble-filled calcium-alginate microfibers with controllable surface morphology (smooth to wavy).
  • Demonstrated transformation of fibers into water-filled segmented fibers, beaded microfibers, and threaded capsules using buoyancy.
  • Achieved controlled destruction of elongated fibers to produce uniform anisotropic micro-particles of various shapes and sizes.

Conclusions:

  • The developed microfluidic setup offers a versatile platform for creating transformable hydrogel microfibers.
  • Buoyancy-assisted fabrication enables the generation of complex hydrogel architectures and precisely shaped micro-particles.
  • This method holds potential for advanced applications in micro-devices and biomaterials.