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Fine particulate matter alters the microecology of the murine respiratory tract

Biao Yang1, Yu Zhang1, Bingyu Li1

  • 1Key Lab of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, No. 146, Huanghe North Street, Shenyang, Liao Ning, People's Republic of China.

Environmental Science and Pollution Research International
|February 2, 2019
PubMed

Insights

Exposure to fine particulate matter (PM2.5) alters respiratory tract microecology in mice. This study links PM2.5 exposure to changes in bacteria, potentially impacting lung injury mechanisms.

Area of Science:

  • Environmental health
  • Microbiology
  • Toxicology

Background:

  • Fine particulate matter (PM2.5) poses a global health risk, particularly to the respiratory system.
  • The impact of PM2.5 on the respiratory tract's microbial community (microecology) is not fully understood.
  • Lung injury models are crucial for investigating environmental exposures' effects.

Purpose of the Study:

  • To investigate the effects of fine particulate matter exposure on respiratory tract microecology.
  • To explore potential mechanisms underlying PM2.5-induced lung injury.
  • To establish a link between PM2.5 and alterations in the lung's microbial composition.

Main Methods:

  • Utilized a lung injury mouse model with BALB/c mice.
  • Groups were randomized into exposure (PM2.5) and control.
  • Analyzed respiratory tract lavage fluid using 16S rRNA sequencing and measured soluble tumor necrosis factor receptor I levels.

Main Results:

  • PM2.5 exposure significantly increased soluble tumor necrosis factor receptor I levels.
  • 16S rRNA sequencing revealed significant alterations in the respiratory tract microecology composition.
  • Lactobacillus was identified as the most abundant bacterial species in the exposed group.

Conclusions:

  • Fine particulate matter exposure alters the respiratory tract's microecology.
  • Changes in microecology are linked to inflammatory responses (e.g., TNF-RI).
  • Understanding these mechanisms may inform future treatment strategies for lung injury.
Keywords:
Lung injuryMicroecologyMousePM2.5Respiratory tract

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