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Related Experiment Videos

Cadmium-induced decrease in the outer facing skin resistance of a bullfrog (Rana catesbeiana).

H Hayashi, M Takada, A Arita

    The Japanese Journal of Physiology
    |January 1, 1978
    PubMed
    Summary
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    Cadmium exposure alters frog skin

    Area of Science:

    • Physiology
    • Toxicology
    • Environmental Science

    Background:

    • Frog skin is a model for studying epithelial transport.
    • Cadmium is a toxic heavy metal with known physiological effects.

    Purpose of the Study:

    • To investigate the effects of cadmium on frog skin's electrical properties.
    • To understand the mechanism of cadmium-induced changes in ion transport.

    Main Methods:

    • Microelectrode technique was used to measure electrical properties.
    • Short circuit current, skin potential, and resistance were recorded.
    • Intracellular potentials and resistance components were analyzed.

    Main Results:

    • Cadmium increased short circuit current and skin potential.

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  • Cadmium decreased overall skin resistance (RM) and intracellular resistance (RM1).
  • Early cadmium exposure (less than 5 min) reduced sodium current resistance (RNa).

    • Conclusions:

    • Cadmium rapidly affects frog skin's electrical properties.
    • The metal appears to target the epidermal sodium channel resistance.
    • Findings contribute to understanding heavy metal toxicology in biological systems.