Related Experiment Video
Updated: Jan 30, 2026

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
Spontaneous remission in diffuse large cell lymphoma: a case report
J Snijder1, N Mihyawi1, A Frolov2
1Baylor St Luke Medical Center, Section of Hematology/Oncology, 1 Baylor Plaza, Houston, TX, 77030, USA.
Background:
Spontaneous remission in solid malignancies has been documented. However, spontaneous remission in aggressive diffuse large b cell lymphoma is exceedingly rare. Previous reports of lymphoma remission suggest that not yet fully characterized tumor-intrinsic and microenvironment mechanisms cooperate with spontaneous regression.
Case Description:
Here, we report the case of an 88-year-old white woman with diffuse large b cell lymphoma (follicular lymphoma transformed) who achieved morphologic spontaneous remission 3 months after her diagnostic core biopsy. We examined 16 similar cases of diffuse large b cell lymphoma suggesting that spontaneous remission is preferentially observed in elderly patients soon after their biopsy microtrauma, especially if malignancies are Epstein-Barr virus driven and activated B-cell type.
Conclusion:
Our case and reported analysis highlight that anti-tumor adaptive T cell responses are potentially augmented in a subset of patients leading to lymphoma regression. In these patients, it is possible that "primed" innate anti-tumor T cell immunity is enhanced in immunogenic lymphoma subtypes after tissue biopsy. Our case and analysis not only reinforce the role of innate T cell anticancer immunity, but also originates potential proof of concept for investigation of unexplored pathways that could favorably impact T cell therapy.
Related Concept Videos
Spontaneity
Diffusion
Diffusion
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion
Data Reporting and Recording
Spontaneous and Induced Mutations

