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Donor-Specific HLA Antibodies as Biomarkers of Transplant Rejection

Olga A Timofeeva1

  • 1Pathology and Laboratory Medicine, Temple University and Hospital, Lewis Katz School of Medicine, 3401 North Broad Street, Room A2-F388, Philadelphia, PA 19140, USA.

Clinics in Laboratory Medicine
|February 3, 2019
PubMed

This article reviews the current evidence to classify donor-specific antibodies (DSAs) using Food and Drug Administration-National Institutes of Health Biomarkers, EndpointS, and other Tools (BEST) resource terms as diagnostic, prognostic, predictive, monitoring, and risk biomarkers for graft rejection. The emphasis is on DSA characteristics, including the DSA levels determined by mean fluorescence intensity and/or titers, the ability to activate a complement cascade (C1q, C3d, and C4d binding), and specific IgG subclasses to define distinct roles of DSAs as biomarkers in clinical practice. In addition, technical limitation of DSA testing is discussed.

Keywords:
BiomarkerC1qDonor-specific antibodyIgG subclassRejectionTiter

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