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[Primary skin lymphomas: Current therapy].

O Dereure1

  • 1Unité Inserm U1058, département de dermatologie, université Montpellier, hôpital Saint-Éloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.

Annales De Dermatologie Et De Venereologie
|February 3, 2019
PubMed
Summary
This summary is machine-generated.

Recent advances in primary cutaneous lymphomas focus on T-cell lymphomas, introducing targeted therapies, immunotherapies, and improved stem-cell transplantation. Innovations also benefit B-cell lymphomas, enhancing treatment options for advanced disease.

Keywords:
B cell lymphomaLymphome BLymphome TLymphomes cutanés primitifsPrimary cutaneous lymphomasT cell lymphoma

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Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Therapeutic progress in primary cutaneous lymphomas (PCL) is primarily driven by advancements in T-cell lymphomas.
  • Innovations target both local and systemic treatment modalities for PCL.

Purpose of the Study:

  • To review recent therapeutic innovations in primary cutaneous lymphomas.
  • To highlight progress in T-cell and B-cell PCL treatments.

Main Methods:

  • Review of current therapeutic strategies for PCL.
  • Focus on local treatments (e.g., chlormethine gel, electron therapy, UVA-1, imiquimod).
  • Emphasis on systemic treatments including targeted drugs (monoclonal antibodies, HDAC inhibitors) and immunotherapies.

Main Results:

  • Significant progress in systemic therapies for T-cell PCL with targeted drugs and immunotherapies.
  • Allogeneic hematopoietic stem-cell transplantation shows superiority in advanced disease.
  • Advancements in B-cell PCL include rituximab (CHOP) and lenalidomide, alongside low-dose radiotherapy.

Conclusions:

  • T-cell PCL has seen major therapeutic innovations, particularly in systemic treatments.
  • Allogeneic stem-cell transplantation is a key option for advanced PCL.
  • Emerging therapies offer improved outcomes for both T-cell and B-cell PCL subtypes.