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Updated: Jan 30, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model
Published on: May 5, 2018
Radiological Advances in Pancreatic Islet Transplantation
Donal Cahill1, Fernanda Zamboni2, Maurice N Collins2
1Department of Radiology, Cork University Hospital, Cork, Ireland.
Abstract:
Type 1 diabetes mellitus (T1DM) is characterized by hyperglycemia, owing to the loss of pancreatic β cells in response to an autoimmune reaction leading to a state of absolute insulin deficiency. T1DM treatment is shifting from exogenous insulin replacement therapy toward pancreatic β-cell replacement, to restore physiologically responsive insulin secretion to variations in blood glucose levels. β-cell replacement strategies include human whole pancreas transplantation, islet transplantation with cell encapsulation and bioengineered pancreas. Interventional radiology and imaging modalities including positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging, ultrasonography, and molecular imaging are imperative to enable successful β-cell replacement. Herein, the role of radiological modalities in the treatment of T1DM and its prospective use for noninvasive post-transplantation graft monitoring is discussed.
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