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Published on: February 4, 2018
Instrument Selection Using the OMERACT Filter 2.1: The OMERACT Methodology.
Dorcas E Beaton1,2, Lara J Maxwell3,4, Beverley J Shea3,4
1From the Institute for Work & Health and Institute for Health Policy Management and Evaluation, University of Toronto, Toronto; Clinical Epidemiology Program, and Centre for Practice-Changing Research, Ottawa Hospital Research Institute; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ontario, Canada; Department of Epidemiology and Biostatistics, and Department of Medical Humanities, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Medicine Service, VA Medical Center; Department of Medicine, School of Medicine, University of Alabama; Division of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama; SDG LLC, Cambridge, Massachusetts, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK; Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines; Sorbonne Université; Pitié Salpêtrière hospital, AP-HP, Rheumatology Department, Paris, France; Sydney Medical School, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, St. Leonards, Australia. dbeaton@iwh.on.ca.
The Outcome Measures in Rheumatology (OMERACT) Filter 2.1 provides a rigorous, transparent process for selecting core outcome measurement sets. This new methodology for instrument selection is feasible and is now being implemented in clinical research.
Area of Science:
- Rheumatology
- Clinical Trial Methodology
- Health Outcomes Research
Background:
- The Outcome Measures in Rheumatology (OMERACT) Filter 2.1 was developed to enhance rigor and transparency in selecting core outcome measurement sets.
- Previous OMERACT processes required refinement to improve decision-making in instrument selection for clinical research.
Purpose of the Study:
- To describe the methodology established by OMERACT for selecting instruments for core outcome measurement sets.
- To introduce the OMERACT Filter 2.1 framework, including its pillars, questions, and measurement properties.
Main Methods:
- The OMERACT Filter 2.1 methodology is based on "3 pillars, 4 questions, 7 measurement properties, 1 answer."
- Key measurement properties include truth (domain match, construct validity), discrimination (reliability, responsiveness, clinical trial discrimination, thresholds), and feasibility.
- A Summary of Measurement Properties table was introduced to consolidate these properties.
Main Results:
- The OMERACT Filter 2.1 methodology was presented and reviewed at OMERACT 2018.
- The process was piloted on two instruments by the Psoriatic Arthritis Working Group.
- The methodology was endorsed through OMERACT Filter 2.1 Instrument Selection votes.
Conclusions:
- The OMERACT Filter 2.1 provides a feasible and structured approach to instrument selection for core outcome measurement sets.
- The methodology is currently being implemented, signifying its practical utility in rheumatology research.
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