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Related Experiment Video

Updated: Jan 29, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Serum S100B Levels in Melanoma.

Anna Lisa Frauchiger¹, Reinhard Dummer¹, Joanna Mangana²

¹Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Methods in Molecular Biology (Clifton, N.J.)

|February 3, 2019

Summary

S100B protein is a potential biomarker for malignant melanoma, aiding in early diagnosis and treatment selection. Further research into S100B can improve patient outcomes for this lethal skin cancer.

Keywords:

Calcium EF hand Follow-up Melanoma S100B Staging Therapy monitoring

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Area of Science:

Oncology
Dermatology
Biochemistry

Background:

Malignant melanoma incidence is rising globally, posing significant socioeconomic challenges.
Despite advances, melanoma remains a highly lethal skin cancer.
Effective biomarkers are crucial for improving melanoma diagnosis, staging, prognosis, and treatment.

Purpose of the Study:

To explore the clinical relevance of the S100B protein in malignant melanoma.
To highlight S100B as a potential biomarker for melanoma management.

Main Methods:

Literature review focusing on S100B protein and its role in melanoma.
Analysis of existing clinical data and research findings related to S100B.

Main Results:

S100B is frequently detected in melanoma patients.
S100B levels correlate with melanoma progression and patient prognosis.
S100B shows potential utility in monitoring treatment response.

Conclusions:

S100B protein holds significant clinical relevance as a biomarker in malignant melanoma.
S100B can aid in early diagnosis, precise staging, and personalized therapy selection.
Further investigation of S100B is warranted to optimize melanoma patient care.