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Characterization of host plasminogen exploitation of Pasteurella multocida

Weifeng Zhu1, Houjun Wei1, Lu Chen2

  • 1Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, 210014, China; National Center for Engineering Research of Veterinary Bio-products, Nanjing, 210014, China.

Microbial Pathogenesis
|February 3, 2019
PubMed

Insights

Pasteurella multocida exploits host plasminogen using Glyceraldehyde 3-phosphate dehydrogenase (GAPDH). This study reveals GAPDH

Area of Science:

  • Microbiology
  • Bacteriology
  • Pathogenesis

Background:

  • Pasteurella multocida causes various diseases and zoonotic infections.
  • Pathogenic bacteria can utilize host plasminogen for tissue invasion and immune evasion.
  • Previous research has not investigated P. multocida's interaction with host plasminogen.

Purpose of the Study:

  • To determine if P. multocida can exploit host plasminogen.
  • To assess the role of Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in plasminogen recruitment by P. multocida.

Main Methods:

  • Assessing P. multocida's ability to recruit plasminogen.
  • Measuring plasmin activity upon urokinase stimulation.
  • Evaluating GAPDH binding to plasminogen.
  • Using GAPDH antiserum to inhibit plasminogen recruitment.

Main Results:

  • P. multocida successfully recruited host plasminogen.
  • Plasmin activity was observed in P. multocida when stimulated.
  • GAPDH demonstrated binding affinity for plasminogen.
  • GAPDH antiserum significantly reduced P. multocida's plasminogen recruitment capacity.

Conclusions:

  • P. multocida utilizes host plasminogen through its Glyceraldehyde 3-phosphate dehydrogenase (GAPDH).
  • This is the first study to report host plasminogen exploitation by P. multocida.
  • GAPDH is identified as a key receptor for plasminogen recruitment in P. multocida.
Keywords:
GAPDHPasteurella multocidaPasteurellosisPlasminogen

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